Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells
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چکیده
منابع مشابه
Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells.
Many studies have shown that an alteration of p53 affects various cellular responses to DNA damage after treatment with ionizing radiation. The human lymphoblast cell WTK1, which contains a mutant p53 (ile237), is 10-fold hypermutable at the thymidine kinase (tk) locus compared with TK6 cells, which are from the same donor but contain wild-type p53. These results implied that the specific p53 m...
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Apoptosis can be triggered by a variety of stimuli such as ionising or UV radiation [17, 30, 35], drugs and hyperthermia [2, 10, 18] and some hormones [41]. These agents activate endogenous nucleases that cleave chromatin in a nonrandom manner resulting in a series of DNA fragments which are integer multiples of 180200 base pairs [40]. Published data concerning the extent of radiation-induced a...
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The p53 tumor suppressor gene has been shown to play an important role in determining cell fate. Overexpression of wild-type p53 in tumor cells has been shown to lead to growth arrest or apoptosis. Previous studies in fibroblasts have provided indirect evidence for a link between p53 and senescence. Here we show, using an inducible p53 expression system, that wild-type p53 overexpression in EJ ...
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PURPOSE Dendritic cells are the most potent antigen-presenting cells for initiating cellular immune responses. Dendritic cells are attractive immunoregulatory cells for cancer immunotherapy, and their efficacy has been investigated in clinical trials. The tumor suppressor gene p53 is pivotal in the regulation of apoptosis, and p53-based immunization is an attractive approach to cancer immunothe...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2007
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gem021